Fig. 4 (C and D)

Fig. 4. Phylogenetic tree of the calpain superfamily. The phylogenetic tree was construeted by the neighbor joining method for domains IIa (A), IIb (B), III (C), and IV (D) independently. Calpains in blue letters are "typical" calpains that contain C2-like and 5EF-hand domains in addition to the protease domain.