4P-306(WS77-10)Poster: October 22 (Sat) 12:15Room Poster (Hall No.1 1F/2F, Hall No.2 1F, Kobe International Exhibition Hall) / Workshop: October 22 (Sat) 11:04Room T (Hall No.2 3F A, Kobe International Exhibition Hall) Transmembrane domain 4 of Presenilin 1 is vital to the γ-secretase activity through direct interaction with Pen-2: Naoto Watanabe, Yuichi Morohashi, Chihiro Sato, Taisuke Tomita, Takeshi IwatsuboKeywords: PRESENILIN; MEMBRANE-PROTEIN-ASSEMBLY